The Karo also have an interesting culture and, with a population of around 1,500 people, are thought to be the Omo Valley's most endangered group.

The Karo are considered masters of body painting, especially when a dance, or celebration is coming up. Everyone paints their body – men, women and children. They use white chalk, yellow mineral rock, black charcoal and ground, red iron ore. The men also have some wild hairstyles and ornaments. The long nails sticking through their bottom lips for ornamentation are very astonishing and shocking for first timers.

Face masks are worn at times and they have clay hair buns with feathers in them. Red clay mixed with butter is put into their hair and clothing is made from animal skin. The women scar their chest believing it makes them beautiful. The men's scars represent an enemy or dangerous animal killed. A man in the tribe can have as many wives as he wants, but must be able to afford them. Most men will only marry two or three.